Tetracaine HCl: Essential Information
Product name |
Tetracaine hcl ( Tetracaine Hrdrochloride) |
CAS No. |
136-47-0 |
Molecular formula |
C15H25ClN2O2 |
Molecular weight |
300.82 |
EINECS number |
205-248-5 |
Melting point |
149°C |
Storage condition |
Room Temperature |
Purity |
>99% |
Standard |
Pharmaceutical Grade |
Appearance |
White or almost white crystal powder |
Pharmaceutical-Grade Anesthetic Purity HCl Powder, CAS 136-47-0: Tetracaine and Lidocaine
Lidocaine hydrochloride undergoes rapid metabolism in the liver, with both metabolites and unchanged drug being excreted through the kidneys. The process of biotransformation includes oxidative N-dealkylation, ring hydroxylation, amide linkage cleavage, and conjugation. N-dealkylation, the primary pathway, produces monoethylglycinexylidide and glycinexylidide. These metabolites exhibit pharmacological and toxicological properties similar to Lidocaine hydrochloride but are less potent. Approximately 90% of administered Lidocaine hydrochloride is excreted as various metabolites, while under 10% remains unchanged. The primary urinary metabolite is a conjugate of 4-hydroxy-2,6-dimethylaniline.
Lidocaine HCl: An Amide Local Anesthetic
As the dose increases, both efficacy and toxicity rise. At sub-toxic plasma concentrations, Lidocaine exhibits anticonvulsive effects.
Blood concentrations exceeding 5μg/ml can induce convulsions.
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