Tetracaine HCl Basic Information:
Pharmaceutical-Grade Anesthetic Purity HCl Powder | CAS 136-47-0 | Tetracaine Lidocaine
Lidocaine hydrochloride undergoes rapid metabolism in the liver, with both metabolites and unchanged drug being excreted through the kidneys. The biotransformation process involves multiple steps: oxidative N-dealkylation, ring hydroxylation, amide linkage cleavage, and conjugation. N-dealkylation, a primary biotransformation pathway, produces monoethylglycinexylidide and glycinexylidide. These metabolites exhibit pharmacological and toxicological actions similar to but less potent than those of Lidocaine hydrochloride. Approximately 90% of administered Lidocaine hydrochloride is excreted as various metabolites, while less than 10% is excreted unchanged. The main metabolite found in urine is a conjugate of 4-hydroxy-2,6-dimethylaniline.
Lidocaine HCl: A Premier Amide Local Anesthetic
As the dosage increases, both its efficacy and toxicity rise correspondingly. At sub-toxic plasma concentrations, Lidocaine exhibits an anti-convulsive effect.
Convulsions can be triggered at blood concentrations exceeding 5μg/ml.
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Welcome to Wuhan Jingkang Technology Co., Ltd., nestled in the vibrant heart of Wuhan. This dynamic city is renowned for its thriving industries, expansive air transportation network, and stunning landmarks, including the historically significant Yellow Crane Tower.
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